Kodein er et opioid som finnes naturlig i opiumsplanten. Fordi Paralgin forte inneholder kodein, er det et sterkere medikament en Paracet og tilsvarende legemidler. I medisinsk sammenheng brukes kodein til behandling av tørrhoste i tillegg til smertebehandling.
For sentralt godkjente legemidler ligger alle styrker og legemiddelformer etter hverandre i samme dokument.
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is indicated for your administration of mild to average ache, the administration of moderate to intense ache with adjunctive opioid analgesics, and the reduction of fever.
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Ammende skal ikke bruke kodeinholdige preparater sammenhengende utover 2–3 dager. Diebarn bør observeres med tanke på slapphet og sedasjon. Kvinner med ultrarask genotype av CYP2D6 vil i høy grad kunne omdanne kodein til morfin.
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Codeine sulfate is often a type of the drug that is commonly utilized. It is on the market in tablet type and indicated to the relief of delicate to reasonably critical discomfort, where by the use of an opioid analgesic is appropriate .
Acetaminophen would not disrupt hemostasis and does not have inhibitory routines from platelet aggregation. Allergic reactions are exceptional occurrences pursuing acetaminophen use.
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Induksjon av metabolismen av paracetamol i lever, både til inaktive metabolitter og til den levertoksiske metabolitten NAPQI.
Blanding med andre dempende rusmidler/legemidler som alkohol eller benzodiazepiner forsterker virkingen av både kodein og stoffet du blander med. Blanding med andre dempende stoffer øker også faren for skadelige effekter som kvalme og brekninger, pustevansker og i verste drop overdose.
Effekten av kodein kommer i all hovedsak ved at det omdannes til morfin i kroppen. Vanligvis omdannes ca. 10 % av kodeindosen til morfin. Hvor stor del av kodeinet som omdannes, varierer fra person til particular person. Derfor kan det være en del variasjon i hvor sterkt folk reagerer på Paralgin forte.